Chinese Journal of Physiology

98 T. KING anp C, PAK

TABLE 1, Proportional effect on the nasal volume of increasing doses of ephedrine

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Time Drugs Blood | Maximum Nasal Maximum (intraven. injection) |pressure|effect of B.P.| volume |effect of N.V. mm Hg| mm Hg mm* Control 78 11:12 Ephedrine HCl, 1 mg (=.089 mg per kg) 11:12:30 92 +14 increasing 11:13:25 90 fs +19 11:15 90 returning 1:14 102 1:15 Ephedrine HCl, 2 mg (=.178 mg per kg) 1:15:30 122 +20 increasing 1:17 110 a +31 1:18 100 | returning 3:18 104 3:19 Ephedrine HCl, 3 mg (=.268 mg per kg) 3:19:35 128 +24 | increasing 3:21:35 110 5 +61

ee Sept. 12,1927. Dog Gy, 11.4 kg, luminal (0,18 gm per kg of body weight)

subcutaneously. *The number of mm is taken from the measurement of the distance

between the original level and the tangent of the curve, which represented the change of nasal volume (N.V.).

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Fig. 1. Comparative effects of ephedrine and ephetonin on the nasal mucous

membrane. December 15, 1927. Dog 6, 11.8 kg, luminal (0.18 gm per kg) subcutaneously). N.V.—Nasal volume. The fall in tracing indicates an increased nasal volume resulting from shrinkage of the mucosa. B.P.—Blood pressure. (A) 11:43 Ephedrine HCl 2 mg intravenously: 34 mm Hg rise in B.P.; 35 mm fall in N.V. tracing. (B) 2:36 Ephetonin HCl 2 mg intravenously: 26 mm Hg rise in B.P.; 29 mm fall in N.V. tracing. (C) 5:35 Ephedrine HCl 2 mg intravenously: 29 mm Hg Tise in B.P.; 32 mm fall in N.V. tracing.