Chinese Journal of Physiology

THE EPHEDRINES ON NASAL MUCOSA 101

ephetonin. The blood pressure effect is much more prolonged in the case of ephedrine than ephetonin. The ratio of the duration of the bleod pressor action is:

Ephetonin _ 4 x

‘Ephedrine ue

JID. Comparison of ephetonin and pseudoephedrine. Four expt. see fig. 2.

a: Nasal volume.

The maximal shrinkage produced by pseudoephedrine was reached 35 to 70 sec., after injection. When pseudoephedrine was injected before ephetonin, the ratio was: Ps-ephedrine

fepnetonin = 0.68 (Average from two experiments).

When ephetonin was injected before pseudoephedrine:

Ps-ephedrine

Bunonn = 0.57 (Average from two experiments).

Average ratio:

Ps-ephedrine — 063

Ephetonin Three minutes after injection the increased nasal volume returned to 75 per cent of the maximal effect in the case of ephetonin and 61 per cent for pseudoephedrine. The duration of the effect of shrinkage ot the mucosa was greater with ephetonin than with pseudoephedrine in the following ratio:

Ps-ephedrine —081

Ephetonin

b. Blood pressure.

Pseudoephedrine is similar to ephedrine and ephetonin in not producing parallel effects upon blood pressure and nasal volume, see figs. 2 and 3 and table 3.

When ephetonin was given before pseudoephedrine:

Eeain = 0.44 (Average from two CDS COLS) When pseudoephedrine was given before ephetonin:

Ps-ephedrine

Ephetonin = 0.68 (Average from two experiments).