Chinese Journal of Physiology

COMPARATIVE TOXICITY OF EPHEDRINES 89

obtained with- frogs, dogs, rats, white and gray rabbits, summarized in table 9. Figure 2 shows how different a picture is obtained with hamsters, in which ephetonin and pseudoephedrine are both more toxic than ephedrine.

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Fig. 8. Comparative magnitudes of M.L.D. of pseudoephedrine HCl in different animals by different methods of administration; (IV) intravenous. Dosage in milligrams per kilogram of body-weight.

III. The toxicity of pseudoephedrine.

So little work has been done upon pseudoephedrine that we made a fuller study of this isomer. One extra series of gray rabbits were used for intravenous injection. Table 8 shows how very toxic the effect can be, greater than for dogs or white rabbits. Figure 3 illustrates the comparative magnitude of the M.L.D. for various animals by