Scientia Sinica

STUDIES ON FUSED RING SYSTEMS II*

A. RESOLUTION OF y-(6é-METHOXY-2-CARBOXY-1,2,3,4-TETRAHYDRO-1NAPHTHYL)-BUTYRIC ACID.

B. PREPARATION OF METHYL d- AND /-1-HYDROXY-2-METHYL-2-CARBOMETHOXY-7-METHOXY-1,2,3,4,9,10,11,12-OCTAHYDROPHENANTHRENE-1- ACETATE. ~

Cuane Cun (48 48)

(Peking Petroleum Institute)

Bachmann, Kushner and Stevenson"! prepared y-(6-methoxy-2-carboxy-3,4dihydro-l-naphthyl)-butyric acid (VII) by the following series of reactions. With this dibasic acid as intermediate, Bachmann and coworkers prepared a mixture of the diastereoisomers of natural estrone. From this mixture, they obtained a crystalline compound which was named estrone A.

CH,—CH Y VAN ; 2 NN os Mg \o% | EL | ee ne IN OES YN, LNA OCH, I OCH; Mgr * FH: OCH, CH, I I LO r C—OC,H, oie | PBr3 | | l + CH Nr UN C—OC;H, OCH; CHa No III - HE(COOCHs)s 4a~ C(COOC2Hs)2 | CH, poe | | cH Nat WN WN OCH, CH, OCH, CH,

IV

*First published in Chinese in Acta Chimica Sinica, Vol. XXI, No. 3, pp. 303—314, 1955.

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