Chinese Journal of Physiology

COMPARATIVE TOXICITY OF EPHEDRINES 85

TABLE 3,

The M.L.D. of ephedrine, ephetonin and pseudoephedrine in gray rabbits by

intravenous injection

Ephedrine HC] Ephetonin HCl Pseudoephedrine HCl Dose per kg of body weight || Rabbits | Rabbits || Rabbits | Rabbits || Rabbits | Rabbits used | died used died used died | _ a 60to 7d | 8 | | 80 3 2 | 2 0 1 0 85 1 1 3 1 90 | 2 | 2 3 1 100 | 1 -| im 2 2 110 to 180 1 | 1 3 3 |

June 1928. Temperature 27.5° to 31°C.

TABLE 4.

The M.L.D. of ephedrine, ephetonin and pseudoephedrine in gray rabbits by subcutaneous injection

Ephedrine HCl | Ephetonin HCl | Pseudoephedrine HCl

Dose [Rabbits Rabbits || Dose |Rabbits| Rabbits || Dose |Rabbits| Rabbits per kg | used died | perkg/| used died per kg used died

|

mg mg mg 180-210 7 1 800-840} 11 1 880 1 0 220 J 0 330 2 0 890 2 0 230 3 2 360 3 2 400 2 2 240 2 2 370 2 2 430 1 1 250 2 2 470 1 1 260 2 2 500 1 1 270 2 il 530 1 al! 250-420) 8 8

July 1928. Temperature 27.5° to 82.5°C. y P

the cat. Subcutaneously the rat and the gray rabbit do not show such a marked difference the M.L.D. being 320 and 230 mg respectively. With ephetonin this was still more the case, there being very little difference shown in these two animals, see table 9, in which is summarized the various results obtained.